Conficker and other worms are typically of most concern to businesses that don't regularly update the desktops and servers in their networks. Once one computer in a network is infected, it often has ready access to other vulnerable computers in that network and can spread rapidly.
Home computers, on the other hand, are usually protected by a firewall and are less at risk. However, a home network can suffer as well. For example, a laptop might pick up the worm from a company network and launch attacks at home.
The most critical and obvious protection is to make sure is applied. Network administrators can also use a to try and stop the worm's attempts to connect to Web sites.
And finally, you can disable Autorun so that a PC won't suffer automatic attack from an infected USB drive or other removable media when it's connected. The Internet Storm Center links to one method for doing so at , but the instructions involve changing the Windows registry and should only be attempted by administrators or tech experts. Comments under those instructions also list other potential methods for disabling autorun.